The genetic factors of bilaterian evolution
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Citation
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Identification
| Title: | Main Title: The genetic factors of bilaterian evolution |
| Description: | Abstract: The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship. |
Responsible Party
| Creators: | Peter Heger (Author), Wen Zheng (Author), Anna Rottmann (Author), Kirsten A Panfilio (Author), Thomas Wiehe (Author) |
| Publisher: | eLife |
| Publication Year: | 2020 |
Topic
| CRC1211 Topic: | Biology |
| Related Subproject: | B3 |
| Subjects: | Keywords: Evolution, Data Management |
| Geogr. Information Topic: | Biota |
File Details
| Filename: | elife-45530-v2.pdf |
| Data Type: | Data Paper - Research Paper |
| File Size: | 5.6 MB |
| Date: | Issued: 16.07.2020 |
| Mime Type: | application/pdf |
| Data Format: | |
| Language: | English |
| Status: | Completed |
Constraints
| Download Permission: | Free |
| General Access and Use Conditions: | According to the CRC1211DB data policy agreement. |
| Access Limitations: | According to the CRC1211DB data policy agreement. |
| Licence: | [Creative Commons] Attribution 4.0 International (CC BY 4.0) |
Geographic
Specific Information - Publication
| Publication Status: | Published |
| Review Status: | Peer reviewed |
| Publication Type: | Article |
| Article Type: | Journal |
| Source: | eLife |
| Volume: | 9 |
| Number of Pages: | 41 (1 - 41) |
Metadata Details
| Metadata Creator: | Yichen Zheng |
| Metadata Created: | 23.07.2021 |
| Metadata Last Updated: | 27.01.2022 |
| Subproject: | B3 |
| Funding Phase: | 1 |
| Metadata Language: | English |
| Metadata Version: | V50 |
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Dataset Statistics
| Page Visits: | 219 |
| Metadata Downloads: | 0 |
| Dataset Downloads: | 1 |
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Adequate reference when this dataset will be discussed or used in any publication or presentation is mandatory. In this case please contact the dataset creator.
Adequate reference when this dataset will be discussed or used in any publication or presentation is mandatory. In this case please contact the dataset creator.
