Recombination, selection, and the evolution of tandem gene arrays
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| Title: | Main Title: Recombination, selection, and the evolution of tandem gene arrays |
| Description: | Abstract: Multigene families—immunity genes or sensory receptors, for instance—are often subject to diversifying selection. Allelic diversity may be favored not only through balancing or frequency-dependent selection at individual loci but also by associating different alleles in multicopy gene families. Using a combination of analytical calculations and simulations, we explored a population genetic model of epistatic selection and unequal recombination, where a trade-off exists between the benefit of allelic diversity and the cost of copy abundance. Starting from the neutral case, where we showed that gene copy number is Gamma distributed at equilibrium, we derived also the mean and shape of the limiting distribution under selection. Considering a more general model, which includes variable population size and population substructure, we explored by simulations mean fitness and some summary statistics of the copy number distribution. We determined the relative effects of selection, recombination, and demographic parameters in maintaining allelic diversity and shaping the mean fitness of a population. One way to control the variance of copy number is by lowering the rate of unequal recombination. Indeed, when encoding recombination by a rate modifier locus, we observe exactly this prediction. Finally, we analyzed the empirical copy number distribution of 3 genes in human and estimated recombination and selection parameters of our model. |
| Identifier: | https://doi.org/10.1093/genetics/iyac052 (DOI) |
| Citation Advice: | Moritz Otto, Yichen Zheng, Thomas Wiehe: Recombination, selection, and the evolution of tandem gene arrays. In: Genetics, Volume 221, Issue 3, July 2022. DOI: https://doi.org/10.1093/genetics/iyac052 |
Responsible Party
| Creators: | Moritz Otto (Author), Yichen Zheng (Author), Thomas Wiehe (Author) |
| Publisher: | Genetics |
| Publication Year: | 2022 |
Topic
| CRC1211 Topic: | Biology |
| Related Subproject: | B6 |
| Subject: | Keyword: Molecular Biology |
File Details
| Filename: | iyac052.pdf |
| Data Type: | Text - Text |
| File Size: | 2.8 MB |
| Date: | Issued: 22.07.2022 |
| Mime Type: | application/pdf |
| Data Format: | |
| Language: | English |
| Status: | Completed |
Constraints
| Download Permission: | Free |
| General Access and Use Conditions: | According to the CRC1211DB data policy agreement. |
| Access Limitations: | According to the CRC1211DB data policy agreement. |
| Licence: | [CRC1211DB] Data policy agreement |
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Specific Information - Publication
| Publication Status: | Published |
| Review Status: | Peer reviewed |
| Publication Type: | Article |
| Article Type: | Journal |
| Source: | Genetics |
| Issue: | 3 |
| Volume: | 221 |
| Number of Pages: | 18 (1 - 18) |
Metadata Details
| Metadata Creator: | Moritz Otto |
| Metadata Created: | 23.02.2023 |
| Metadata Last Updated: | 23.02.2023 |
| Subproject: | B6 |
| Funding Phase: | 2 |
| Metadata Language: | English |
| Metadata Version: | V50 |
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| Page Visits: | 94 |
| Metadata Downloads: | 0 |
| Dataset Downloads: | 0 |
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